轮状病毒Rotaviruse.ppt
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1、轮状病毒 Rotaviruse,Rotaviruses are the most common cause of severe diarrhoea disease in infants and young children worldwide; in 2004, rotavirus infections were estimated to cause approximately 527 000 (475 000-580 000) deaths, predominantly in developing countries.,形态,核心为dsRNA,外有双层衣壳,内外两层呈放射状排列,轮状病毒,分
2、组: A、B、C组:可引起人、动物腹泻, 最常见A组(有称为小儿轮状病毒) D-G组:仅引起动物腹泻 A组抵抗力: 耐乙醚、弱酸 室温中传染性可保持7个月 -20。C长期保存,掌握轮状病毒所致疾病,A组轮状病毒,所致疾病: 婴幼儿腹泻 传播途径:粪-口途径 机理:病毒在十二指肠粘膜细胞中增殖 影响肠道对水、盐的正常吸收 腹泻(粪便绿或白色),常伴发热,严重者可出现脱水或酸中毒,B组轮状病毒,引起成人腹泻 我国1982年首先发现,特异性预防,尚无疫苗接种,思考题,在我国引起婴幼儿秋冬季腹泻的病毒主要是 A、戊型肝炎病毒 B、ECHO病毒 C、柯萨奇病毒 D、A组轮状病毒 E、B组轮状病毒 答案:
3、D,Rotaviruses are the most common cause of severe diarrhoea disease in infants and young children worldwide; in 2004, rotavirus infections were estimated to cause approximately 527 000 (475 000-580 000) deaths, predominantly in developing countries. Although the viral strains show considerable diversity, 5 serotypes are responsible for the majority of human rotavirus disease. Primarily transmitted by the fecal-oral route, rotaviruses affect the vast majority of children worldwide before the age of 3 years, and in most developing countries before the first birthday,From WHO,
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