ABSTRACT - Harlem Children Society摘要-哈莱姆儿童协会.ppt
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1、Creating an Ion & Molecular Sensor By Combining Phenyl Mercaptoacetamide & Benzyl Mercaptoacetamide Ligands with Preferable Metals,Submitted by: Chris Roca Mentor: Duncan Quarless, Ph.D. Undergraduate Asst. Mentor: Alicia Bowen,ABSTRACT,Phenyl mercaptoacetamide (PMA) & Benzyl mercaptoacetamide (BMA)
2、 were synthesized to observe their imitative relevance for fabricating the structure and reactivity of metallocysteinate proteins that are involved in metal transport. These ligands were used to observe if the type of reaction that takes place between them and the metal cations, which are Zinc (Zn2+
3、) and Cobalt (Co2+), can produce an ion detecting molecule. Xylenol Orange was used as a color indicator to determine the extinction (metal concentration dependence) which is used from Beers law A= EBC and examine the visible spectroscopy of the various solutions, which determines the relative conce
4、ntration of complexed and free indicators. Although no major results are yet found, zinc appears to be the least discriminate of the metal cations with respect to xylenol orange. Cobalt showed a lower extinction than Zinc which meant more concentration was needed than Zinc. The purpose of such an ex
5、periment is to see if these ligands can be an alternative for ion detection when combined with a metal, which for the moment seems to be Zinc.,INTRODUCTION,Ion recognition continues to be a major research goal for many supramolecular chemist groups around the world. Phenyl mercaptoacetamide (PMA) &
6、Benzyl mercaptoactamide (BMA) are ligands or in other words they are a molecule that bonds to the central metal atom of a compound. What is expected to happen is that the ligands, BMA and PMA, would react with the metals, Zinc (Zn) and Cobalt (Co), to form a molecule that detects specific ions when
7、the two come into contact. If successful this experiment can help produce an ion detecting agent that is a novel sulfur based ligand, and these assays will likely have relevance in analytical, environmental chemistry, as well as biomedical imaging and drug discovery.,MATERIALS,CHEMICALS Aniline Benz
8、ylamine Thioglycolic acid (mercaptoacetic acid) Cobalt acetate Zinc acetate pH 5 buffer Methanol LAB EQUIPMENT Thermometers Weighing scales Assorted glassware (Volumetric flasks, Erlenmeyer flasks, Buchner funnels, etc) Ultra violet Light (UV/vis) spectrophotometer Infrared (IR) spectroscopy apparat
9、us Nuclear Magnetic Resonance (NMR) Spectroscopy apparatus,SYNTHESIS OF BMA & PMA,Benzyl Mercaptoacetamide,Phenyl Mercaptoacetamide,METHODS,BMA & PMA were synthesized from benzyl amine and aniline, respectively Samples were recrystallized from methanol Checked melting point of samples Tested purity
10、of samples using GC-MS (gas chromatograph with mass spectrophotometer) Created pH 5 buffer for use in metal reactions Created metal solutions using zinc acetate and cobalt acetate in methanol Xylenol Orange indicator was added to metal solutions which were then tested in uv/vis spectrophotometer to
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- ABSTRACT Harlem Children Society摘要-哈莱姆儿童协会 Society 摘要 莱姆 儿童 协会
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