心血管疾病中药材循证应用的最新进展-英文.ppt
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1、Recent Progress in the Evidence-Based Application of Herbal Medicines for Cardiovascular Diseases,Professor Shufeng Zhou, MD, PhD School of Health Sciences WHO Collaborating Center for Traditional Medicine RMIT University, Bundoora, Victoria 3083 Australia Phone: Tel: +61 3 9925 7794; Fax: +61 3 992
2、5 7178 Email: shufeng.zhourmit.edu.au,11 April 2008,An Overview of Global Herbal Use,All folk medicine includes the use of plant products. 11,145 species of herbal plants worldwide; 534 species of plants for Chinese Medicine. WHO definition botanical origin, without adulteration of any synthetic dru
3、gs. Legal status: food supplements (FDA market value 1015%/per year. 2 billion in Australia. 40% Caucasian and 80% Asians use or used herbs.,Active Components,Biotransformation,Excretion,Absorption,Response/Toxicity,?,?,?,?,Preclinical Stage,Phase I,Phase II,Phase III,Phase IV,Clinical Trials of Her
4、bal Medicines,General acceptance of humans,Safety and Efficacy,More data on safety and Efficacy,Challenges for Herbal Clinical trials,Dosage & formulation: standardized or individualized? Biomarkers? Safety profiles? Pharmacokinetics data?,Herbs,PK,PD,Pharmacokinetics of TPNS formula in stroked pati
5、ents,Dosage (mg/kg),PT,TT,fib,APTT,Injection rate (mg/min),PT,TT,Fib,APTT,Integrated Conc. (g/ml),PT,PT,TT,Fib,APTT,Herbal medicines as multi-component therapeutics,It is possible to integrate PK and PD for herbal medicines. Challenges: multi-component therapeutics? Which marker compounds to measure
6、? How to determine therapeutic window?,Herb-Drug Interactions: Underestimated,Patients: 70% do not reveal their herbal use to their doctors/pharmacists in Western countries Legal issue: rigorous preclinical and clinical assessments not required Difficulties in the studies; poor clinical studies Lack
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- 心血管疾病 中药材 应用 最新进展 英文
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