高表达Ang1基因的间充质干细胞株的建立及其肺内转化研究.ppt
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1、高表达Ang1基因的间充质干细胞的建立及其肺内转化研究,徐金富 瞿介明 李惠萍等 同济大学附属上海市肺科医院 复旦大学附属华东医院,High promise for angiopoietin-1(Ang1) in lung injury intervention,Ang1 decreased in LPS induced lung injury anti-inflammation: inhibits endothelial permeability, neutrophil adherence and IL-8 production Anti-apoptosis role to endothel
2、ial cells,Thurston G, Rudge JS, Ioffe E, et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nat Med. 2000, 6: 460-463. Daly C, Wong V, Burova E, et al. Angiopoietin-1 modulates endothelial cell function and gene expression via the transcription factor FKHR (FOXO1). Gene Dev
3、. 2004, 18(9): 1060-1071. Pizurki L, Zhou Z, Glynos K, et al. Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. Brit J Pharmacol. 2003, 139(2): 329-336.,Mesenchymal stem cells (MSC),No ethical difficulties harvest MSC from the individual to be treated No rej
4、ection problems Self migrate to where the injury is located,Rojas M, Xu J, Woods CR, et al. Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol 2005; 33: 145152 Robert JD,Annemarie BMmesenchymal stem cells:biology and potential clinical uses. Experimen
5、tal Hematology, 2000, 28(8):87,Our hypothesis,+Ang1,MSCs,By Lentiviral vector,MSCs transduced with Ang1,Mice,LPS induced lung injury,In vivo intervention,Methods and results,pCR2.1-Ang1 : Prof. Federico Bussolino in Institute for cancer research and treatment, Italy,Sequencing results: 100% coincide
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- 表达 Ang1 基因 间充质干 细胞株 建立 及其 转化 研究
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