通过葡萄糖诱导氧化应激,刺激血管内皮细胞中的NADPH氧化酶4活性和表达的增加.ppt
《通过葡萄糖诱导氧化应激,刺激血管内皮细胞中的NADPH氧化酶4活性和表达的增加.ppt》由会员分享,可在线阅读,更多相关《通过葡萄糖诱导氧化应激,刺激血管内皮细胞中的NADPH氧化酶4活性和表达的增加.ppt(24页珍藏版)》请在三一文库上搜索。
1、Increased activity and expression of NADPH oxidase 4 stimulated by glucose induces oxidative stress in vascular endothelial cells Jian LI Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Ministry of Health, Beijing 100730, China,-cell,liver,obesity,-Cell Dysfunction,Insulin Resistance,
2、FFA VLDL,FFA VLDL,Glucose,Oxidative stress,Hypothesis,Redox “rheostat“ in cells,Where are reactive oxygen species generated?,Mitochondrial respirtion-chain enzyme complex xanthine oxidase, NOS, lipoxygenase Phagocyte NADPH oxidase NADPH oxidase of non-phagocytic cells NADPH oxidase is a major source
3、 of vascular ROS production.,NOX-type NADPH oxidases as superoxide-producing enzymes,Structure of the NADPH oxidase,The NOX family of NADPH oxidases,gp91phox homology,EF-hands,Nox1 colon Nox2 phagocytes Nox3 inner ear Nox4 kidney and vascular cells,Nox5 testis and lymphoid tissues,O2,O2-,NADPH,e-,A,
4、B,C,D,DPI:NOX inhibitor; Rotenone: inhibitor of mitochondrial respirtion-chain enzyme complex; L-NAME:NOS inhibitor; Oxypurinol: xanthine oxidase inhibitor,NADPH oxidase is a major source of vascular ROS production induced by glucose,A: negative control; B: HUVEC; C: 20mM glucose treated HUVEC; D: p
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- 通过 葡萄糖 诱导 氧化 应激 刺激 血管 内皮 细胞 中的 NADPH 氧化酶 活性 表达 增加
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