滤泡性淋巴瘤.ppt
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1、,Follicular Lymphoma,Contents,incidence and epidemiology,diagnosis and molecular biology,staging and risk assessment,treatment,follow-up and long-term implications,Sites and enrollment by region.,Follicular lymphoma is the second most common subtype of lymphoma (although its incidence may be lower i
2、n some parts of the world such as Asia) and represents about 20% to 25% of cases of non-Hodgkin lymphomas in the U.S. and Europe.,Incidence and Epidemiology,Diagnosis and Molecular biology,Histological and pathological,Immunohistologic findings,GENETIC ABNORMALITIES,Grading of follicular lymphoma,An
3、nals of Oncology Advance Access,CD19+ 、CD20+ 、CD79a+、CD10+、Bcl6+,BCL2 rearrangement、t( 14;18)、t( 8;14),Histological and pathological,Grading of follicular lymphoma,Architectural Patterns in Follicular,Spectrum of Follicle Morphology,Immunoarchitectural Patterns of Follicualr lymphoma,1.Describe cont
4、ents for a Chart - Description of the companys sub contents - Description of the companys sub contents 2.Describe contents for a Chart - Description of the companys sub contents - Description of the companys sub contents,Immunohistologic findings,IHC,GENETIC ABNORMALITIES,GENETIC ABNORMALITIES,Theme
5、Gallery is a Design Digital Content & Contents mall developed by Guild Design Inc.,GENETIC ABNORMALITIES,01,02,03,Click to add Text Click to add Text Click to add Text,Click to add Text Click to add Text Click to add Text Click to add Text,GENETIC ABNORMALITIES,BCL2 mutations correlate with transfor
6、mation risk and disease-specific death in FL.,01,02,03,Click to add Text Click to add Text Click to add Text,Click to add Text Click to add Text Click to add Text Click to add Text,GENETIC ABNORMALITIES,Graphic summary of common genetic lesions in follicular lymphoma,01,02,03,Click to add Text Click
7、 to add Text Click to add Text,Click to add Text Click to add Text Click to add Text Click to add Text,BCL2 mutations in FL correlate with activation-Induced cytidine deaminase expression and frequently alter the amino acid sequence of the protein. Mutations in the BCL2 coding sequence at diagnosis
8、are associated with shortened time to transformation and Earlier death due to lymphoma.,Description of the contents,Description of the contents,GENETIC ABNORMALITIES,01,02,03,Click to add Text Click to add Text Click to add Text,Click to add Text Click to add Text Click to add Text Click to add Text
9、,Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text Click to add Text,“ThemeGallery is a Design Digital Content & Contents mall developed by Guild Design Inc.”,Staging and Risk Assessment,A New Prognostic Index for FL,Description of the companys sub contents,De
10、scription of the companys sub contents,Description of the companys sub contents,Content Title,Content Title,01,02,03,Click to add Text Click to add Text Click to add Text,Click to add Text Click to add Text Click to add Text Click to add Text,Click to add Text Click to add Text Click to add Text Cli
11、ck to add Text Click to add Text Click to add Text,Staging and Risk Assessment,FLIPI-2 better than FLIPI-1?,01,02,03,Stage III Stages IIIIV,Induction therapy,Consolidation/Maintenance,Relapsed disease,Treatment,First line,Stage III,Stage III,In stage III patients with large tumour burden or adverse
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