HPLC分析常见药物的方法集.pdf
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1、 2003 Waters Corporation.Waters is a trademark of Waters Corporation. YMCis a trademark of YMC, Co.,Ltd.15 1. Vitamins Oil-soluble vitamins 21 Vitamin A fatty acid ester.21 Retinol. 21 Carotene21 -Carotene 22 Vitamin D 22 Tocopherols 23,24 Tocopherol and tocopherol acetate .24,25 Vitamin K. 25 A dri
2、nk including vitamins. 26 Water-soluble vitamins . 25,26,27,28,29 Allantoin and water-soluble vitamins 29 Thiamine and its modifide compounds 30 Riboflavin and related compounds . 30 Nicotinic acid and derivatives. 30 Pantothenyl alcohol . 30 Coenzyme A and derivatives 31 L-Ascorbic acid and erythor
3、bic acid . 31 2,4-Dinitrophenylhydrazone of L-ascorbic acid . 31 2. Carbohydrates Monosaccharides and disaccharides.32 Monosaccharides . 32 Unsaturated chondro-disaccharides 33 Sugar alcohols . 33 Oligosaccharides 33,34,35 Fructooligosaccharides. 34 Oligosaccharides of soft drink. 34 Maltooligosacch
4、arides35,36,37 Cyclodextrins .37,38 Pyridylamino(PA)-Sugar chains38,39 Polydextrose40 Pullulans 40,41 Chondroitin.41 Chondroitin sulfate A 41 Chondroitin sulfate B 41 Chondroitin sulfate C42 Hyaluronic acid.42 Heparin42 Heparan sulfate.42 List of Applications 16 2003 Waters Corporation.Waters is a t
5、rademark of Waters Corporation. YMCis a trademark of YMC, Co.,Ltd. 3. Nucleic acids Keratan sulfate.43 Keratan polysulfate.43 Nucleosides and bases.43 Nucleic acid bases 43 Orotic acid.44 Nucleotides 44,45,46 Oligonucleotides46 Poly(A) .46 Sugar nucleotides46,47 Plasmid pBR322 restriction fragments.
6、47 4. Amino acids, Peptides, Proteins Amino acids48 Taurine in nutritious drink48 PTC-amino acids48 PTH-amino acids48 NBD-amino acids.49 Peptides and proteins49 Glutathione, oxidized and reduced form 49 Angiotensins.49,50 Insulins50,51 Peptides 51,52,53,55,56,59 Human immunoglobulins.53,54 Normal Hu
7、man IgA54 Cytochrome c55 Peptide fragments from myoglobin.55 Glycine oligomers56 Casein.56 Proteins for molecular weight marker56,57,58 Proteins 58 Human IgM() myeloma protein .54 5. Organic acids, Fatty acid derivatives Organic acids.60 Pyruvic acids.60 Unsaturated fatty acid methyl esters .61 Meth
8、yl linolenate and methyl -linolenate61 Triacylglycerols 61 List of Applications Click on the links below to go directly to that section of the notebook. To start a new search, click on List of Applications Bookmark to the left List of Applications 2003 Waters Corporation.Waters is a trademark of Wat
9、ers Corporation. YMCis a trademark of YMC, Co.,Ltd.17 6. Food additives Food preservatives 62,67 p-Hydroxybenzoic acid esters62,63 EDTA-chelates63 Antioxidants 63,64,65 Color additives65 Annatto extract 66 Aspartame in a soft drink66,67 Stevioside and rebaudioside A.67 Glycyrrhizic acid67 7. Natural
10、 products Purine Alkaloids .68 Alkaloids 68 Chlorophyll a and b.68 Crude Drugs (Glycosides)69 Paeoniflorin.69 Paeoniflorin in Toki-shakuyaku-san70 Saponins from roots of rubus suavissimus S.Lee70 Saikosaponins.70 Ginsenosides 71 Flavonoids.71,72 Baicalin72 Flavanone glycosides.72,73 Isoflavones from
11、 miso, fermented soybean paste73 Catechins73,74 2-Phenylethyl glycosides 74 Sennosides 74,75 Arbutin and related compounds75 Paeonol76 Aflatoxins76 8. Steroids Steroids.77,80 Adrenocorticosteroids.77,78,79,80 Hydrocortisone and prednisone78 Androgens81 Synthetic androgens 81,82 Estrogens and progest
12、ins.82 Estrogens.82,83 Norgestrel and ethinylestradiol .83 Phenacyl esters of bile acids from pig gall83 List of Applications To start a new search, click on List of Applications Bookmark to the left Click on the links below to go directly to that section of the notebook. List of Applications 18 200
13、3 Waters Corporation.Waters is a trademark of Waters Corporation. YMCis a trademark of YMC, Co.,Ltd. 8. Steroids (Cont.) Ecdysones.84 Sterols84 Cardiac glycosides.85 Steroids from toad venom 86 9. Drugs, Metabolites Pain-killing drugs .87,90 Indometacin 87 A cough/cold medication87 Ingredients in a
14、cough/cold medication87,88 Analgesics 88 Benzethonium chloride 89 Benzalkonium chloride 89 Ingredients in drug for rhinitis89 Ingredients in an eye drop.89 Codeine.90 Collunarium.90 Naphazoline hydrochloride and chlorpheniramine maleate90 Histamine antagonists .91 Acidic non-steroidal anti-inflammat
15、ory drugs .91,93 Antipsychotic drugs.92 Antiepileptics.92 Tricyclic antidepressants.93 Calcium antagonists94 Hypolipidemic drugs.95 Lovastatin95 Antiarrhythmic drugs.94,97 Local anesthetics 97 Diuretics 96,97 Antineoplastic and related compounds.96 Folic acid and its antagonists .96 Nicotinic acid a
16、nalogues98,100 Basic compounds.98 Disinfectants 98 Acyclovir 99 Carnitine chloride.99 Xanthine oxidase inhibitor and related compounds .99 Anti-human immunodeficiency virus (HIV) agents.100 Acidic and Basic drugs .101 Chlorhexidine101 Purine catabolites .102 Catecholamines .102 Hippuric and methylhi
17、ppuric acids101,102 List of Applications Click on the links below to go directly to that section of the notebook. To start a new search, click on List of Applications Bookmark to the left List of Applications 2003 Waters Corporation.Waters is a trademark of Waters Corporation. YMCis a trademark of Y
18、MC, Co.,Ltd.19 10. Antibiotics Antibacterial agents .104 Sulfonamides 103,104,105 Antibiotics 105 Nalidixic acid antibiotics .105,106 Cephalosporin antibiotics106,107,108,109,110 Cefoxitin sodium.111,112 Penicillin antibiotics111 Amoxicillin111 Cephalosporin C.112 Ceftriaxone 112 Erythromycin antibi
19、otic drugs113 Tetracycline antibiotics113 Vancomycin113 11. Pesticides, Environmental Copper 8-quinolinolate.114 Herbicides .114 Atrazine derivatives114 Triazine herbicides114,115 Urea herbicides.115 Acid amide herbicides .115 Carbamate herbicides115 Carbamate insecticides 116 Fungicides116 Imazalil
20、116 2,4-Dinitrophenylhydrazones of aldehydes and ketones117 Polyaromatic hydrocarbons.117,118 List of Applications Click on the links below to go directly to that section of the notebook. To start a new search, click on List of Applications Bookmark to the left List of Applications 20 2003 Waters Co
21、rporation.Waters is a trademark of Waters Corporation. YMCis a trademark of YMC, Co.,Ltd. 12. Miscellaneous Benzoic acid derivatives .119,120 Methoxybenzoic acid isomers.119 Chlorobenzoic acid isomers 119,122 Hydroxybenzoic acids.120 Resorcylic acid isomers120 Phenol derivatives.121 Cresol isomers 1
22、21,124 Polyphenols .122 Dimethylphenol isomers122 Aminoalcohols .123 Urea and related compounds .123 A nonionic detergent.123 Polyethyleneglycols .123 Metal-PAN chelates.124 Coordination compounds.124 Hinokitiol.124 Phthalic acid isomers.125 Chlorophenol isomers125 Chloracetophene isomers.125 Fuller
23、enes126 Aromatic amines.126 Terphenyl isomers127 List of Applications Click on the links below to go directly to that section of the notebook. To start a new search, click on List of Applications Bookmark to the left List of Applications Vitamins 1 2003 Waters Corporation.Waters is a trademark of Wa
24、ters Corporation. YMCis a trademark of YMC, Co.,Ltd.21 Oil-soluble vitamins 1. Menadione (Vitamin K3) 2. Retinol (Vitamin A) 3. Retinol acetate 4. Menaquinone (Vitamin K2) 5. Tocopherol 6. Ergocalciferol (Vitamin D2) 7. Cholecalciferol (Vitamin D3) 8. Tocopherol (Vitamin E) 9. Tocopherol acetate 10.
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