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1、World Anesthesia Drug Market Rures adquireret umbraculi, etiam tremulus matrimonii libere senesceret appApril 2010 Kalorama Information A division of MarketR 38 East 29th Street Sixth Floor New York, New York 10016 212.807 .2660 t 800.298.5603 t 212.807 .2676 f Copyright 2010 Kalorama Information R
2、eproduction without written permission, in any media now in existence or hereafter developed, in whole or in any part, is strictly prohibited THE WORLD ANESTHESIA DRUG MARKET A KALORAMA INFORMATION MARKET INTELLIGENCE REPORT The World Anesthesia Drug Market has been prepared by Kalorama Information.
3、 We serve business and industrial clients in the United States and abroad with a complete line of information services and research publications. Kalorama Information Market Intelligence Reports are specifically designed to aid the action-oriented executive by providing a thorough presentation of es
4、sential data and concise analysis. Author: Melissa Elder Publication Date: April 2010 38 East 29th Street New York, New York 10016 (800) 298-5699 Outside the U.S. (212) 807-2657 FAX: (212) 807-2676 www.KaloramaI E-MAIL: Copyright 2010 Kalorama Information Reproduction without written permission, in
5、 any media now in existence or hereafter developed, in whole or in any part, is strictly prohibited TABLE OF CONTENTS CHAPTER ONE: EXECUTIVE SUMMARY1 Introduction.1 Scope and Methodology1 Size and Growth of the Market3 Issues and Trends Affecting Market6 Leading Competitors.7 CHAPTER TWO: INTRODUCTI
6、ON THE WORLD ANESTHESIA DRUG MARKET8 Introduction and History to Anesthesia Drugs.8 Types of Anesthesia.11 General Anesthesia11 Local Anesthesia.11 Adjunctive Therapies in Anesthesia12 Routes of Administration13 Inhalation.13 Mask Inhalation13 Laryngeal Mask 13 Endotracheal Administration14 Controll
7、ed Respiration .14 Intravenous16 Topical Application.16 Transdermal/Transmucosal Application.17 Distribution Channels.18 Demographics and Statistics.19 Worldwide Demographics.19 Medical Procedures by Type.22 Complications in Anesthesia.26 CHAPTER THREE: GENERAL ANESTHESIA30 Overview.30 Induction of
8、General Anesthesia.31 Preoxygenation.31 Loss of Consciousness 31 Description of Products.31 Diprivan31 Ultane/Sevorane31 Lusedra.32 Copyright 2010 Kalorama Information Reproduction without written permission, in any media now in existence or hereafter developed, in whole or in any part, is strictly
9、prohibited Precedex32 Ethrane .32 Forane.33 Pentothal.33 Suprane.33 Ketalar34 Brevital .34 Generic Drug Impact and Availability36 Research and Development 39 Precedex39 CNS 705639 AZD3043.40 Market Size and Growth.42 Total Market42 Market by Delivery Method45 Market by Geographical Region.48 Competi
10、tive Analysis.51 CHAPTER FOUR: LOCAL ANESTHESIA55 Overview.55 Techniques of Administration.57 Topical Application.57 Transdermal/Transmucosal58 Simple Local Infiltration.58 Regional Injections.59 Spinal and Epidural Anesthesia.60 Intrathecal Block.61 Epidural, Peridural Block.61 Description of Produ
11、cts.63 AminoAmides.63 Xylocaine/LidoSite/Lidoderm/Dentipatch.63 Zingo.64 Carbocaine/Isocaine/Polocaine64 Marcaine/Sensorcaine64 Citanest.65 Naropin.65 Septocaine.65 Amino Esters.66 Novocaine.66 Nesacaine66 Cocaine Hydrochloride.66 Combinations 67 Synera/Pliaglis67 EMLA67 Copyright 2010 Kalorama Info
12、rmation Reproduction without written permission, in any media now in existence or hereafter developed, in whole or in any part, is strictly prohibited Generic Drug Impact and Availability69 Research and Development 72 Market Size and Growth.74 Total Market74 Market by Delivery Method78 Market by Geo
13、graphical Region.81 Competitive Analysis.84 CHAPTER FIVE: ADJUNCTIVE THERAPIES IN ANESTHESIA.87 Overview.87 Description of Products.88 Neuromuscular Blocking Agents.88 Preanesthetic Sedation and Anesthesia Maintenance 92 Anesthesia Reversal Agents94 Generic Drug Impact and Availability98 Research an
14、d Development 102 Market Size and Growth.104 Total Market104 Market by Geographical Region.108 Competitive Analysis.111 CHAPTER SIX: ANESTHESIA DRUGS: TOTAL MARKET SIZE AND FORECAST115 Total Market Size and Forecast.115 Anesthesia Market by Product Type.118 Anesthesia Market by Geographical Region.1
15、23 Competitor Analysis126 CHAPTER SEVEN: ISSUES AND TRENDS AFFECTING THE ANESTHESIA DRUG MARKET .109 Introduction.109 Regulation of Anesthesia Drugs.110 Dentistry and Anesthesia110 Anesthesia and Complications in Pediatric Applications112 Allergic Reactions in Anesthesia112 Recent Propofol Recall.11
16、3 Anesthesia and the Benefits to Depression Patients.113 Copyright 2010 Kalorama Information Reproduction without written permission, in any media now in existence or hereafter developed, in whole or in any part, is strictly prohibited Anesthesia and Sleep.114 Gender Differences in Anesthesia Reacti
17、on114 Trends in Conscious Sedation 115 Long-term Effects of Anesthesia118 CHAPTER EIGHT: CORPORATE PROFILES.109 Introduction.109 Abbott Laboratories111 AstraZeneca.113 Baxter International115 Eisai Co.117 Endo Pharmaceuticals Holdings, Inc.119 Hospira, Inc121 Merck/Schering-Plough123 Roche 125 LIST
18、OF COMPANIES 127 Copyright 2010 Kalorama Information, Reproduction without prior written permission, in any media now in existence or hereafter developed, In whole or in any part, is strictly prohibited. LIST OF EXHIBITS CHAPTER ONE: EXECUTIVE SUMMARY1 Table 1-1: The Total World Market for Anesthesi
19、a Drugs 2007-2014.4 Figure 1-1: The Total Market for Anesthesia Drugs 2007-2014 .5 CHAPTER TWO: INTRODUCTION THE WORLD ANESTHESIA DRUG MARKET8 Table 2-1: World Population by Selected Geographical Region, 2010 - 205020 Figure 2-1: World Population by Selected Geographical Region, 20102050.21 Table 2-
20、2: Procedures by Type, Average Annually 2006-2009 .23 Figure 2-2: Procedures by Type Worldwide, Average Annually 2006-200924 Figure 2-3: Procedures by Type U.S., Average Annually 2006-200925 Table 2-3: Worldwide Anesthesia Complications and Related Mortality27 Figure 2-4: Worldwide Anesthesia Compli
21、cations and Related Mortality28 CHAPTER THREE: GENERAL ANESTHESIA30 Table 3-1: Marketed Brands for General Anesthesia Drugs (Brand Name, Generic Name, and Manufacturer) 35 Table 3-2: Selected Generic Drug Manufacturers and Products for General Anesthesia37 Table 3-1: Brand vs. Generic General Anesth
22、etic Market 2007-200938 Table 3-3: General Anesthesia Drugs in Development 41 Table 3-4: The Market for General Anesthesia Drugs 2007-201443 Figure 3-2: The Market for General Anesthesia Drugs 2007-2014.44 Table 3-5: The Market for General Anesthesia Drugs Estimated Products Sales by Delivery Method
23、, 2009 46 Figure 3-3: The Market for General Anesthesia Drugs Market Share by Delivery Method, 2009.47 Table 3-6: The Market for General Anesthesia Drugs Estimated Products Sales by Geographic Region, 2009.49 Figure 3-4: The Market for General Anesthesia Drugs Market Share by Geographic Region, 2009
24、50 Table 3-7: The Market for General Anesthesia Drugs Estimated Revenues and Market Share of Leading Suppliers 2007-2009.52 Copyright 2010 Kalorama Information, Reproduction without prior written permission, in any media now in existence or hereafter developed, In whole or in any part, is strictly p
25、rohibited. Figure 3-5: The Market for General Anesthesia Drugs Estimated Market Share by Leading Suppliers 2009.53 CHAPTER FOUR: LOCAL ANESTHESIA55 Table 4-1: Selected Marketed Local Anesthesia Drugs (Brand Name, Generic Name and Manufacturer)68 Table 4-2: Selected Generic Drug Manufacturers and Pro
26、ducts for Local Anesthesia.70 Table 4-1: Brand vs. Generic Local Anesthetic Market 2007-200971 Table 4-3: Local Anesthesia Drugs in Development.73 Table 4-4: The Market for Local Anesthesia Drugs 2004-2011 76 Figure 4-2: The Total Market for Local Anesthesia Drugs 2004-2011.77 Table 4-5: The Market
27、for Local Anesthesia Drugs Estimated Products Sales by Delivery Method, 200979 Figure 4-3: The Market for Local Anesthesia Drugs Market Share by Delivery Method, 200980 Table 4-6: The Market for Local Anesthesia Drugs Estimated Products Sales by Geographic Region, 2009.82 Figure 4-4: The Market for
28、Local Anesthesia Drugs Market Share by Geographic Region, 200983 Table 4-7: The Market for Local Anesthesia Drugs Estimated Revenues and Market Share of Leading Suppliers 2007-2009.85 Figure 4-5: The Market for Local Anesthesia Drugs Estimated Market Share by Leading Suppliers 200986 CHAPTER FIVE: A
29、DJUNCTIVE THERAPIES IN ANESTHESIA.87 Table 5-1: Selected Marketed Adjunctive Therapies in Anesthesia (Type, Brand Name, Generic Name, and Manufacturer)96 Table 5-2: Selected Generic Drug Manufacturers and Products for Adjunctive Therapies in Anesthesia100 Table 5-1: Brand vs. Generic Adjunctive Ther
30、apies in Anesthesia Market 2007-2009.101 Table 5-3: Adjunctive Therapies in Anesthesia in Development 103 Table 5-4: The Market for Adjunctive Therapies in Anesthesia 2007-2014106 Figure 5-2: The Market for Adjunctive Therapies in Anesthesia 2007-2014.107 Table 5-5: The Market for Adjunctive Therapi
31、es in Anesthesia Estimated Products Sales by Geographic Region, 2009.109 Copyright 2010 Kalorama Information, Reproduction without prior written permission, in any media now in existence or hereafter developed, In whole or in any part, is strictly prohibited. Figure 5-3: The Market for Adjunctive Th
32、erapies in Anesthesia Market Share by Geographic Region, 2009110 Table 5-6: The Market for Adjunctive Therapies in Anesthesia Estimated Revenues and Market Share of Leading Suppliers 2009.112 Figure 5-4: The Market for Adjunctive Therapies in Anesthesia Estimated Market Share by Leading Suppliers 20
33、09113 CHAPTER SIX: ANESTHESIA DRUGS: TOTAL MARKET SIZE AND FORECAST Table 6-1: The Total World Market for Anesthesia Drugs 2007-2014.116 Figure 6-1: The Total Market for Anesthesia Drugs 2007-2014 .117 Table 6-2: Anesthesia Drug Market by Type 2007-2014 119 Figure 6-2: Anesthesia Drug Market by Type
34、 2007-2014.120 Figure 6-3: Anesthesia Drug Market by Type 2009121 Figure 6-4: Anesthesia Drug Market by Type 2014122 Table 6-3: Anesthesia Drug Market Estimated Products Sales by Geographic Region, 2009.124 Figure 6-5: Anesthesia Drug Market Market Share by Geographic Region, 2009.125 Table 6-4: Lea
35、ding Suppliers Anesthesia Revenues and Significant Segments of Participation, 2009109 Figure 6-6: Leading SuppliersAnesthesia Revenues, 2009 110 Copyright 2010 Kalorama Information Reproduction without prior written permission, in any media now in existence or hereafter developed, in whole or in any
36、 part, is strictly prohibited. CHAPTER ONE Executive Summary INTRODUCTION The number of procedures requiring anesthetic administration continues to climb with the growing and aging population in many regions of the world. The population of the world plays an important role in the growing incidence a
37、nd prevalence of disease and will continue to reflect positively on growth for anesthesia drugs. The number of surgical procedures worldwide has grown to exceed more than 300 million annually with 53 million of these in the United States. An additional 64 million are estimated to occur in the Europe
38、an Union, accounting for 21% of surgical procedures worldwide. SCOPE AND METHODOLOGY This Kalorama Information report The World Anesthesia Drug Market - focuses on three primary segments of anesthesia: General Anesthesia Local Anesthesia Adjunctive Therapies in Anesthesia Executive Summary 2 Copyrig
39、ht 2010 Kalorama Information, Reproduction without prior written permission, in any media now in existence or hereafter developed, In whole or in any part, is strictly prohibited. ? General anesthesia is the progressive, reversible stage of central nervous system depression that occurs following the
40、 administration of drugs used for this purpose. ? Local anesthesia depresses sensory nerves and blocks conduction of pain impulses from their site of origin. Sensory nerves are affected first. When only an anesthetic drug is used, the patient remains conscious. ? In addition to the various anestheti
41、c agents available, several other drugs may be given in the perioperative period to facilitate and/or augment the anesthetic process. The report covers both currently marketed and late stage development anesthesia drugs in detail. Revenues for each segment were generated using dollar and unit sales
42、for each product. Forecasted figures were generated using a combination of projected surgical procedures, patent and exclusivity expirations, pricing trends, new developments and other factors. The report includes statistical information for surgical procedures, incidence of conditions requiring sur
43、gery, and other relevant information. Statistical information is presented as a worldwide overview, with special emphasis on the U.S. The market segments provide an overview, description of products on the market, description of products in development, market estimates and forecasts, and competitiv
44、e analysis of leading providers. The report also includes current issues and trends affecting the industry. The information for this report was gathered using both primary and secondary research including comprehensive research of secondary sources such as company literature, databases, investment r
45、eports, and medical and business journals. Telephone interviews and email correspondence were the primary method of gathering information. For the purpose of this study Kalorama Information conducted interviews with more than 50 key industry officials, consultants, health care providers, and governm
46、ent personnel. These sources were the primary basis in Executive Summary 3 Copyright 2010 Kalorama Information, Reproduction without prior written permission, in any media now in existence or hereafter developed, In whole or in any part, is strictly prohibited. gathering information specifically rel
47、ating to revenue and market share data presented in this report. Specific interviews with pharmaceutical company representatives included marketing directors, division managers, and product representatives. All market data pertains to the world market at the manufacturers level. The base year for da
48、ta was 2009. Historical data was provided for the years 2007 and 2008, with forecast data provided for 2010 through 2014. Compound annual growth rates (CAGRs) are provided for the 2007-2009, 2007-2014 and 2009-2014 periods for each industry segment covered. Competitive analysis is provided for the y
49、ear 2009 with a projected competitive analysis for 2014. The forecasted market analysis for 2009-2014 was highly influenced by the probability of approval and sales of products in late stage development, product marketing, and demographic trends. SIZE AND GROWTH OF THE MARKET The total world market for anesthesia drugs is estimated to total $4.1 billion in 2009. (See Table 6-1and Figure 6-1 for details.) Sales for anesthesia drugs increased 2.4% from 2007 to
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