《专业英语》考查课专业论文-高分子材料的研究进展.doc
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1、河南工程学院专业英语考查课专业论文高分子材料的研究进展学生姓名: 学 院: 机械工程学院 专业班级: 材控1242 专业课程: 专业英语 任课教师: 2015年11月20日Abstract : This paper contains an ester bond and an amide bond and an ester bond and an amide bond hybrid bond polymer biomaterials synthesis, modification and biocompatibility of research results. Rich in hydrophi
2、lic groups degradable and degradation products can be absorbed by organisms or metabolic polymer material can meet the needs of tissue engineering , uncoupling protein -containing molecules, drug molecule active group polymer biomaterials will have a more large potential applications.Key words : pol
3、ymer biomaterials ; polyester ; polyamide1 Introduction Biological material known as biomedical materials, refers to an organism for treatment, diagnosis and replacement tissues and organs corrupted or promotional material of their functions. It is divided into metal materials, polymer materials, ce
4、ramics and composites four kinds 1. The late 1980s, people of biotechnology to the study of biological materials, combined with biological elements and functions to build the desired biologically active material, which made the concept of tissue engineering. Tissue engineering marks the medicine wil
5、l be out of the scope of the organization of organ transplantation, tissues and organs into the manufacturing era, thus tissue engineering in the 21st century high-tech industry has great potential. Polymer science of the 20th century a strong impetus to the booming development of biological materia
6、ls, bio-polymer material carrying drugs and release of biological scaffold material has broad application prospects. Currently, the medical polymer materials around the world has more than 90 varieties, more than 1800 kinds of products, according to the Western countries consumption growth rate of 1
7、0% to 20% annually. Tissue engineering polymer desired biologically active materials not only have good biocompatibility, but also biodegradable, and easily absorbed or metabolic degradation products, and in favor of cell adhesion, growth, proliferation and gene expression and regulation, etc. An es
8、ter bond and an amide bond is readily hydrolyzable bond, and therefore the polymer is a polymer containing multiple biomaterials ester bond or an amide bond. Polyglycolic acid and its copolymers hydroxy acids, such as polylactic acid (PLA) and glycolic acid and lactic acid copolymer (PLGA) is typica
9、l of biological material containing ester bonds, poly amino acids are typical amide bond-containing biological material. Their synthesis, modification and application in the biomedical aspects of a more extensive research.2 polyester-based biomaterials Poly lactic acid and glycolic acid and lactic a
10、cid copolymer is generally used glycolide or lactide in the organic tin catalyst obtained by cationic polymerization mechanism, they can degrade in the physiological environment, the degradation The product can be metabolized and eliminated from the body. Since 1970 polyglycolic acid has become comm
11、ercially available surgical sutures 2,3, with glycolic acid and lactic acid monomer biodegradable polymer caused widespread concern, the researchers biodegradable degradation mechanisms depending on the desired mechanical properties and design the polymer 4. PLA and polyglycolic acid (PGA) polymers
12、are highly crystalline, by hydrolysis in the physiological environment of the first occurrence in the amorphous regions, since there are side-methyl-PLA, PGA exhibited stronger than the hydrophobic, and therefore of PLA hydrolysis difficult than hydrolysis of the PGA. The copolymerization of glycoli
13、c acid with lactic acid, by adjusting the ratio of the two monomers, is expected to give the desired rate of hydrolysis of biological material 5. PLA, PGA and PLGA has good biocompatibility and safety, and their carrying of biological scaffolds have been widely studied 6 on drugs. Drug carrying part
14、icle micro-encapsulated nano particles, and, generally spray drying method, three methods of W / O / W double emulsion solvent evaporation method and aerosol extraction method 7. Drug-loaded particles can enter the organism by the oral, subcutaneous and intramuscular way. Akiko Japanese scientists,
15、who reported to the PLA and PLGA microencapsulation of material for luteinizing hormone release in vitro studies, the results showed that, pH value of the medium, salt concentration and other factors will affect the release of the drug. Hongkee et al 9 reported a mixture of PLA and PGA micro encapsu
16、lating material to control bovine serum albumin, transfer and pancreatic protein ferritin analog protein release, we found that the microencapsulation can achieve a continuous release of an antigen, can effectively replace the multiple injections of antigens, have potential applications in terms of
17、vaccine inoculation. Zambaux et al reported the preparation and characterization of load protein C (a plasma factor) of PLA nanoparticles in 1999, and found that protein C is adsorbed on the hydrophobic interaction based on PLA nanoparticles. Prabba, who reported carrying different sizes of PLGA nan
18、oparticles on DNA in 2002, the result is the smaller the particle size, the higher the efficiency of DNAs carrying. Breitenbach et analysis of linear polyesters carrying proteins and other macromolecules hydrophilic macromolecules on the basis of unfavorable factors, by changing the polyester struct
19、ure and increase the hydrophilic polymer, effectively regulate the degradation rate of the polymer and the release rate of the drug. They were synthesized with polyethylene oxide (PEO) branched star structure polyester and dextrin or polyvinyl alcohol-based chain, polyester comb polymer branched, re
20、search shows that they can be used as intestinal ideal drug carrier material outside. Vila, who designed and fabricated with polyethylene glycol (PEG) for the coating of PLA nanoparticles coated with chitosan and chitosan nanoparticles PLGA nanoparticles carrying on their research activity of the pr
21、otein The results showed that the stability of hydrophilized engineered nanoparticles and proteins contained negative amount are greatly increased. Sahli, who studied the PLA and PEO-PLA nanoparticles in mice with the after effects of plasma factor found no hydrophilic structure of PLA nanoparticles
22、 clumping factor is very sensitive, PEO-PLA nanoparticles containing hydrophilic structure of cohesion factors have a stronger role in the resistance, it can be a long time stability in the blood. Biocompatibility studies with PLGA as A segment to the B segment of PEO ABA block copolymer Zange and o
23、thers with fibroblast cell culture model, found that increasing the content of PEO, the degradation rate of the copolymer is increased, as fiber cell adhesion and growth thereon situation is more favorable.In PLA or PLGA-based materials, through enhanced modified, it can be made to obtain the requir
24、ed scaffold for tissue engineering. Wang et al. Reported a hydroxyapatite ceramic particles to enhance PLA, the material can be given biological activity, can induce the formation of bone tissue hydroxyapatite similar on the surface. Campbell found that a mixture of the polycaprolactone, PLGA and hy
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