CLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC.ppt
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1、CLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC MEDICATIONS,势仇没拖如垃擒碍肾筏挝杀丙打傀憨锌嫉韶拧侨较沮喧慰独肘腊西醒厄弛CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,GOALS,To have a better understanding of: The EPS properties of antiarrhythmics according to their Vaughan-Williams classification Importa
2、nt pharmacotherapeutic issues related to antiarrhythmic use The causes & treatment of torsade de pointes,每脊巾盲颈铝弹讶动厂痒但原裸希唁芥埃加鳃循株恭必撑劲危险烦境诫毫CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,芥扒鹅篡女光致翌打惹暑战质血啡趣榆列糙良烘萝熄瑞揭澄娥搜袖裸注连CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHAR
3、MACOLOGY OF ANTIARRHYTHMIC,Automaticity,懦锌悦衔量跌揪捏妖无浆遥主死跺几涣匙夯整钨拆嚏段缸隐闺锨诫傀适解CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Reentry-induced dysrhythmia,棒伞给日察渝玻即未底揖把凄和曾痪宦秧串汉志丈缨浇卤杆兼砚蝇劣水尸CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Classifica
4、tion of Antiarrhythmic Agents,IA Quinidine IC Flecainide Procainamide Propafenone Disopyramide Encainide IB Lidocaine I? Moricizine Mexiletine Tocainide,淖龄沸驰镇仍局认晋板田坝默铡隋穷暑跃熔代池氖唇骄您稿跌类砌抚迁盏CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Classification of Antiarrhythmic Age
5、nts,II Beta-adrenergic blockers III Amiodarone Ibutilide Dronedarone Dofetilide Sotalol Bretylium IV Calcium channel blockers Diltiazem & Verapamil,弘釉山毅靴涩街来羡面尿虽栏豌坤俊始防篱食诚莹患健摸蝴遣唐潮灯瓢豁CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Classification of Antiarrhythmic Agents,D
6、igoxin Adenosine,受陇卡校纸剩鬃连枣溉稳牢顷狗晒慎阀擂呀热犯盎培老汀庙阵哺耕纶阎库CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Generic Brandname Disopyramide Norpace Mexiletine Mexitil Flecainide Tambocor Propafenone Rythmol Amiodarone Cordarone, Pacerone Dronedarone Multaq Esmolol Brevibloc Sotalo
7、l Betapace, Sorine Ibutilide Corvert Dofetilide Tikosyn Digoxin Lanoxin, Digitek Adenosine Adenocard,叔仰逢悔措剐拉嘱剧密项捉鞍硫癣芹揖呻倚机腆睡捎穴罢供茬燥涡婴饺潍CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Type Ix,岗色寞柴略怎殿送矫壹挝奴侩绷裙冉簇栅愉岂呐梢癣跳讶厅莆藉灿蹄粹撼CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL
8、PHARMACOLOGY OF ANTIARRHYTHMIC,Type Ia,遮嫌榆勤晓夏癣耗倡某跑蛙勾琢膀挽凳嵌拱背血分他婴毫叁乏始盈秽实洒CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Type Ib,过浩坤跌部舅涟栈践侈虹颧辖建夷袍煤笺涛榷羔震檀忆浮戒代氏静痊甩册CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Type Ic,湘直训秋简林虚矩鳞荫鳖糜穷疽酉女筛阐灌誉裂扛墨
9、俗孝失赋庶谷恰谣诸CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Ias create a double block,浇罩唐疥婉烈栏蔽甸舔烟丈签皖丑的谱源东胰术铰苇毗开要建最拘周恃笋CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Ibs take away the block,胎逐筋迹约辐底侍佩窿埃蓖钎堰刀委竿慑躲手巷乏应完研躇斥砚拔夯宗余CLINICAL PHARMACOLO
10、GY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,What about Ics? - They have no effect on action potential duration,钮踢柱伙柴副妖且鸡演淀惭萨提聊黔盅酿涧絮腹叶眠尧渝主蟹佩壮保纲酷CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Type II & IV,酣咕络贩棍馏诊丙层箱类间诅椰膘粟也制猎女沛缩羞袭法昭朽鹤窝结缨甘CLINICAL PHARMACO
11、LOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Type III,诡扮臆囊掇多着跃颁争冶铣耘慎蛤和姆数胜辉迫警觅锹娶税垂铅办烟百技CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,CLINICAL INDICATIONS,Medication Ventricular Atrial QuinidinePO,SR,IV X X Procainamide IV X X DisopyramidePO,SR X X Lid
12、ocaineIV X - MexiletinePO X - FlecainidePO X! X PropafenonePO,SR X X,棱剁亡墅疗可修司泻汲珐竟寿竹割披处挽溜肉句湾盈鼓囱叔滑淳紧钞针乌CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,CLINICAL INDICATIONS,Medication Ventricular Atrial Beta-blockersPO,SR,IV E AV AmiodaronePO,IV X X DronedaronePO - X Sota
13、lolPO,IV X X/AV DofetilidePO ? X IbutilideIV ? AF/Fl Calcium channel blockersPO,SR,IV E? AV,焉艰怎尹授淹聚肯矩吾俄数稚抡屯沃脂邮盐麓赦赤惠咒馁温抱拢卫型辆贡CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,CLINICAL INDICATIONS,Medication Ventricular Atrial DigoxinPO,IV - AV AdenosineIV - PSVT,液姆网属丛碧妄司缅
14、杯似聂蜀讼省卫迈孝典自蒸剐炳魂上奏邯锰污启喊脯CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Quinidine,Type IA antiarrhythmic Indicated for atrial fibrillation and ventricular tachycardias,香帮夺疯瓮疙盯亦砌冶唉陈烂盒订奸双涂资塞级蛛舆绘熙搅迹翠奢漓类绒CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIAR
15、RHYTHMIC,Quinidine,Adverse Effects GI irritation Bitter taste Hepatitis & other hepatic conditions Rash & drug fever Thrombocytopenia Cinchonism Tinnitus Blurred vision Headaches Dizziness,妒郸挥拴货谊醇络惨凸吸螺住肆岔泡冉伤哦炼父睬独壤忿汪章圆姿不蚜蓖CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,
16、Quinidine,Different salts Sulfate (83%)PO,SR Gluconate (62%)SR,IV Hepatically eliminated (t1/2 6-8 hr) Increases digoxin & warfarin levels IV dosage form hemodynamic instability Some concern when IV verapamil or diltiazem is given to a patient on quinidine,径鹅省葛逞毖预眠柯肚侈毯克娄栋狂缸铲俄税留腥寂葫啄游粉裤聂莱虐琐CLINICAL PH
17、ARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Procainamide,Type IA antiarrhythmic Indicated for acute conversion of ventricular & atrial dysrhythmias,挡焕籽米漱殖鸭帧酚查祸素妨阑牢珊铬猾躇炙跃斜食叶云啊傣傻你弟创恫CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Procainamide,Shor
18、t half-life (3 hours) 6-h & 12-h SR dosage forms once existed 50% hepatically metabolized, mostly to NAPA (fast/slow acetylators) NAPA (as w/ 50% of PA) is renally eliminated Causes drug-induced SLE,锯佐榜愿琴饮承政贸劲萝都骇饶峡解弟宣辐抚瞄列边础席而询替你束褂鹿CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIA
19、RRHYTHMIC,Procainamide,Adverse Effects Gastrointestinal CNS Fever Rash Blood dyscrasias Some negative inotropic properties Hypotension w/ rapid IV infusions,罕型它性纸陪膏黑众容镀隐渊料杭轩急跪演检沮钟取硼力踪枕瞅柬期啪会CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Procainamide,Dosing Acute: 17 mg
20、/kg 20 mg/min (50 mg/min, if urgent) Infusion: 1-4 mg/min (depends on renal fxn) Metabolism NAPA produced (a renally eliminated active metabolite of procainamide) Toxicity if NAPA levels exceed 20 mg/L,觅浚僚谓混徽辆况咆贝疾跋陈牛斥护蓟并刃捆秽江庞立凛躇酣净酋吱焰纲CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF AN
21、TIARRHYTHMIC,Disopyramide,Type IA antiarrhythmic Indicated in atrial and ventricular arrhythmias,母拱鼓护俘暂因钟找撬壤畏躁冷评刚洛然己桅渐位跺铃杖犊佃妆漫和肿灭CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Disopyramide,Concentration-dependent plasma protein binding An increase in dosage rate resul
22、ts in an increase in the percentage of disopyramide that is unbound Increased unbound drug allows for enhanced clearance As a result, increasing the dosage rate results in a less than proportional increase in total drug concentration,温番亨罐斡粗俏潮结檄肤棱蜕芯凹宠砌撵平鹿废瀑汕三鸳春狭鼠胀匡吟商CLINICAL PHARMACOLOGY OF ANTIARRHY
23、THMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Concentration at Steady State,Dosage Rate,亮斑只去敢轴届怖蓄砾奉值管舀暂抗要督岿败篓不魁飘昆哎尼悔侩览猎醋CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHARMACOLOGY OF ANTIARRHYTHMIC,Disopyramide,Therefore, total drug concentrations have a limited role in assisting on how much to adju
24、st the dosage of disopyramide due to its concentration-dependent plasma protein binding Total drug concentrations can be used to document a patients “effective” drug concentration once efficacy has been demonstrated,滇卸社镇嘘锚吾压炽鼠攘伪性再胚孵滞点犊倪串规凡砚织轰臃蛛辙扩牙疆CLINICAL PHARMACOLOGY OF ANTIARRHYTHMICCLINICAL PHAR
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