1、BSENISO6143:2025GasanalysisComparisonmethodsfordeterminingandcheckingthecompositionofcalibrationgasmixturesbsi.NationalforewordThisBritishStandardistheUKimplementationofENISO6143:2025.ItisidenticaltoISO6143:2025.ItsupersedesBSENISO6143:2006,whichiswithdrawn.TheUKparticipationinitspreparationwasentru
2、stedtoTechnicalCommitteePTI15,NaturalGasandGasAnalysis.Alistoforganizationsrepresentedonthiscommitteecanbeobtainedonrequesttoitscommitteemanager.ContractualandlegalconsiderationsThispublicationhasbeenpreparedingoodfaith,howevernorepresentation,warranty,assuranceorundertaking(expressorimplied)isorwil
3、lbemade,andnoresponsibilityorliabilityisorwillbeacceptedbyBSIinrelationtotheadequacy,accuracy,completenessorreasonablenessofthispublication.Allandanysuchresponsibilityandliabilityisexpresslydisclaimedtothefullextentpermittedbythelaw.Thispublicationisprovidedasis,andistobeusedattherecipientsownrisk.T
4、herecipientisadvisedtoconsiderseekingprofessionalguidancewithrespecttoitsuseofthispublication.Thispublicationisnotintendedtoconstituteacontract.Usersareresponsibleforitscorrectapplication.TheBritishStandardsInstitution2025PublishedbyBSIStandardsLimited2025ISBN9780539244649ICS71.040.40Compliancewitha
5、BritishStandardcannotconferimmunityfromlegalobligations.ThisBritishStandardwaspublishedundertheauthorityoftheStandardsPolicyandStrategyCommitteeon30June2025.Amendments/corrigendaissuedsincepublicationDateTextaffectedEUROPEANSTANDARDENISO6143NORMEEUROPEENNEEuropaischenormJune2025ICS71.040.40Supersede
6、sENISO6143:2006EnglishVersionGasanalysis-ComparisonmethodsfordeterminingandcheckingthecompositionofcalibrationgasmixturesISO6143:2025Analysedesgaz-MethodesdeComparaisonpourlaGasanalyse-VergleichsverfahrenzurBestimmungunddeterminationetlaverificationdelacompositiondesUberpriifungderZusammensetzungvon
7、melangesdegazd,etalonnage(ISO6143:2025)Kalibriergasgemischen(ISO6143:2025)ThisEuropeanStandardwasapprovedbyCENon3June2025.CENmembersareboundtocomplywiththeCEN/CENELECInternalRegulationswhichstipulatetheconditionsforgivingthisEuropeanStandardthestatusofanationalstandardwithoutanyalteration.Up-to-date
8、listsandbibliographicalreferencesconcerningsuchnationalstandardsmaybeobtainedonapplicationtotheCEN-CENELECManagementCentreortoanyCENmember.ThisEuropeanStandardexistsinthreeofficialversions(English,French,German).AversioninanyotherlanguagemadebytranslationundertheresponsibilityofaCENmemberintoitsownl
9、anguageandnotifiedtotheCEN-CENELECManagementCentrehasthesamestatusastheofficialversions.CENmembersarethenationalstandardsbodiesofAustria,Belgium,Bulgaria,Croatia,Cyprus,CzechRepublic,Denmark,Estonia,Finland,France,Germany,Greece,Hungary,Iceland,Ireland,Italy,Latvia,Lithuania,Luxembourg,Malta,Netherl
10、ands,Norway,Poland,Portugal,RepublicofNorthMacedonia,Romania,Serbia,Slovakia,Slovenia,Spain,Sweden,Switzerland,TiirkiyeandUnitedKingdom.富EUROPEANCOMMITTEEFORSTANDARDIZATIONCOMITEEUROPEENDENORMALISATIONEuropaischeskomiteefurnormungRef.No.ENISO6143:2025ECEN-CENELECManagementCentre:RuedelaScience23,B-1
11、040Brussels2025CENAllrightsofexploitationinanyformandbyanymeansreservedworldwideforCENnationalMembers.BSENISO6143:2025ENISO6143:2025(E)EuropeanforewordThisdocument(ENISO6143:2025)hasbeenpreparedbyTechnicalCommitteeISO/TC158AnalysisofgasesincollaborationwithTechnicalCommitteeCEN/TC238Testgases,testpr
12、essures,appliancecategoriesandgasappliancetypesthesecretariatofwhichisheldbyAFNOR.ThisEuropeanStandardshallbegiventhestatusofanationalstandard,eitherbypublicationofanidenticaltextorbyendorsement,atthelatestbyDecember2025,andconflictingnationalstandardsshallbewithdrawnatthelatestbyDecember2025.Attent
13、ionisdrawntothepossibilitythatsomeoftheelementsofthisdocumentmaybethesubjectofpatentrights.CENshallnotbeheldresponsibleforidentifyinganyorallsuchpatentrights.ThisdocumentsupersedesENISO6143:2006.Anyfeedbackandquestionsonthisdocumentshouldbedirectedtotheusersnationalstandardsbody/nationalcommittee.Ac
14、ompletelistingofthesebodiescanbefoundontheCENwebsite.AccordingtotheCEN-CENELECInternalRegulations,thenationalstandardsorganizationsofthefollowingcountriesareboundtoimplementthisEuropeanStandard:Austria,Belgium,Bulgaria,Croatia,Cyprus,CzechRepublic,Denmark,Estonia,Finland,France,Germany,Greece,Hungar
15、y,Iceland,Ireland,Italy,Latvia,Lithuania,Luxembourg,Malta,Netherlands,Norway,Poland,Portugal,RepublicofNorthMacedonia,Romania,Serbia,Slovakia,Slovenia,Spain,Sweden,Switzerland,TiirkiyeandtheUnitedKingdom.EndorsementnoticeThetextofISO6143:2025hasbeenapprovedbyCENasENISO6143:2025withoutanymodification
16、ContentsPageForeword.Introductionvi2 Normativereferences13 Termsanddefinitions14 Symbolsandabbreviatedterms35 Principle46 Generalprocedure56.1 Determinationoftheanalysisfunction56.2 Validationoftheanalysisfunction96.2.1 Purpose96.2.2 Validationoftheresponsemodel96.2.3 Examiningconformancewithuncert
17、aintyrequirements106.2.4 Driftcontrolofthemeasuringsystem106.2.5 Validationofapplicabilitytomismatchingcalibrationgases116.3 Determinationofthecompositionofacalibrationgasmixture126.4 Supplementaryinstructions136.4.1 Exceptionaluncertainties136.4.2 Correlationbetweenreferencegasmixtures137 Specialpr
18、ocedures147.1 Checkingofapre-assignedcomposition147.2 Comparisonofseveralcalibrationgasmixtures148 Reportofresults15Annex A (informative)ProceduresfordataevaluationAnnex B (informative)Examples22Annex C (informative)Computerimplementationofrecommendedmethods31Annex D (informative)Additionalinformati
19、onondataevaluation33BibliographyForewordISO(theInternationalOrganizationforStandardization)isaworldwidefederationofnationalstandardsbodies(ISOmemberbodies).TheworkofpreparingInternationalStandardsisnormallycarriedoutthroughISOtechnicalcommittees.Eachmemberbodyinterestedinasubjectforwhichatechnicalco
20、mmitteehasbeenestablishedhastherighttoberepresentedonthatcommittee.Internationalorganizations,governmentalandnon-governmentabinliaisonwithISO,alsotakepartinthework.ISOcollaboratescloselywiththeInternationalElectrotechnicalCommission(IEC)onallmattersofelectrotechnicalstandardization.Theproceduresused
21、todevelopthisdocumentandthoseintendedforitsfurthermaintenancearedescribedintheISO/IECDirectives,Part1.Inparticular,thedifferentapprovalcriterianeededforthedifferenttypesofISOdocumentshouldbenoted.ThisdocumentwasdraftedinaccordancewiththeeditorialrulesoftheISO/IECDirectives,Part2(seewww.iso.org/direc
22、tives).ISOdrawsattentiontothepossibilitythattheimplementationofthisdocumentmayinvolvetheuseof（八）patent(三).ISOtakesnopositionconcerningtheevidence,validityorapplicabilityofanyclaimedpatentrightsinrespectthereof.Asofthedateofpublicationofthisdocument,ISOhadnotreceivednoticeof（八）patent(三)whichmayberequ
23、iredtoimplementthisdocument.However,implementersarecautionedthatthismaynotrepresentthelatestinformation,whichmaybeobtainedfromthepatentdatabaseavailableatwww.iso.org/patents.ISOshallnotbeheldresponsibleforidentifyinganyorallsuchpatentrights.Anytradenameusedinthisdocumentisinformationgivenfortheconve
24、nienceofusersanddoesnotconstituteanendorsement.Foranexplanationofthevoluntarynatureofstandards,themeaningofISOspecifictermsandexpressionsrelatedtoconformityassessment,aswellasinformationaboutISOsadherencetotheWorldTradeOrganization(WTo)principlesintheTechnicalBarrierstoTrade(TBT),seeWWW.isoQrgisofor
25、eword.htmLThisdocumentwaspreparedbyTechnicalCommitteeISO/TC158,Analysisofgases,incollaborationwiththeEuropeanCommitteeforStandardization(CEN)TechnicalCommitteeCEN/TC238,Testgases,testpressures,appliancecategoriesandgasappliancetypes,inaccordancewiththeAgreementontechnicalcooperationbetweenISOandCEN(
26、ViennaAgreement).Thisthirdeditioncancelsandreplacesthesecondedition(ISO6143:2001),whichhasbeentechnicallyrevised.Themainchangesareasfollows:updateofdefinitions,inparticularthosetakenfromtheVIM;一updateofthebibliographyandthecorrespondingreferencesinthetext;一updateoftheinformationinAmIeXConthecomputer
27、programmeB_LEAST;informationonalternativesoftware(AnnexP);一amendmentof612(now7.2)Comparisonofseveralcalibrationgasmixturesandrelatedstatementsinotherpartsofthedocument一amendmentoftherecommendationsconcerningthenumberofreplicatemeasurementspersample;一revisionoftherequirementsforthereportofresults(Tes
28、treport);一newAnneXD(informative)Additionalinformationondataevaluation;一deletionofAAUncertaintyspecificationsforreferencegasmixtures;一additionalreferencestorelevantISOstandards(ISO12963,ISO14912,ISO15796);一correctionofFormula(4)forthepowerfunctions.recommendationaddedtoAnneXeSBandCnottouseB_LEASTfore
29、valuationsusingtheexponentialfunction(duetorecentlydemonstratederrors)ortocalculatetheparameteruncertainties(standarduncertaintiesandcovariances)separately.Anyfeedbackorquestionsonthisdocumentshouldbedirectedtotheusersnationalstandardsbody.Acompletelistingofthesebodiescanbefoundatwww.iso.org/members
30、html.IntroductionIngasanalysis,calibrationofanalyticalsystemsismostoftenconfinedtothedeterminationofastraightlinethroughtheorigin,orofastraight-linesegment,usingonlytheminimumnumberofcalibrationstandards(oneforastraightlinethroughtheorigin,twoforalinesegment).Thisapproachwasalsoadoptedinthefirstedi
31、tion(ISO6143:1981).However,thisdocumentisintendedforaspecifictask:thederivationofcalibrationgasesfromappropriatereferencegases.Consequently,themultipliereffectoferrorsincalibrationgases-anerrorinacalibrationgascancauseerrorsinthousandsofanalyticalresults-implieshighdemandsonthemetrologicalqualityoft
32、heanalysisofcalibrationgases.Inthedevelopmentofthesecondedition(ISO6143:2001),itwasthereforedecidedtousethebestavailablemeasurementstrategyanddataevaluationmethod.ThemainchangesintherevisionofISO6143:1981relatedtocalibrationaswellastouncertaintyevaluation:一includingnon-linearresponsecurvesand/orfunc
33、tions;一replacinginterpolationbyregression;一takingintoaccounttheuncertaintyonthecalibrationstandards;includingvalidationofcalculatedresponsecurvesand/orfunctions;calculatinguncertaintiesbyuncertaintypropagation.Aftertwentyyears,theprinciplesandproceduresspecifiedinthesecondeditionofthisdocumentaresti
34、llfitforpurpose.Thecurrentrevisionthereforemainlyconcernsadditionalsupportinginformation.Asaconsequenceofadoptingnon-linearresponsemodels,advancedregressiontechniques(errorsinbothvariables)anduncertaintypropagation,themaincalculationprocedurescanonlybeperformedonacomputer,usingaspecificprogram.Adedi
35、catedprogram(B_LEAST)isavailableandprovidedWithoutcostasapartofthisdocument(seeAnnexC)ThesoftwareB_LEASTcanbeobtainedviathefollowinglink:https:StandardS.iso.org/iso/6143ed-3en.Informationonotherpubliclyavailablesoftwarethatcanbeusedforatleastthevastmajorityofthecalculationsrequiredbythisdocumentisgi
36、veninAnnexD.Asanalternative,sufficientinformationisgiveninthisdocumenttoenabletheusertodevelopaprogramontheirown.GasanalysisComparisonmethodsfordeterminingandcheckingthecompositionofcalibrationgasmixtures1 ScopeThisdocumentspecifiesmethodsfor: determiningthecompositionofacalibrationgasmixturebycompa
37、risonwithappropriatereferencegasmixtures;一calculatingtheuncertaintyofthecompositionofacalibrationgasmixtureinrelationtotheknownuncertaintyofthecompositionofthereferencegasmixtureswithwhichitwascompared; checkingthecompositionattributedtoacalibrationgasmixturebycomparisonwithappropriatereferencegasmi
38、xtures; consistencytestingandoutliersearchinsuitesofcalibrationgasmixturesofcloselyrelatedcomposition.NOTE1Inprinciple,themethoddescribedinthisdocumentisalsoapplicabletotheanalysisof(largely)unknownsamplesinsteadofprospectivecalibrationgasmixtures(i.e.gasmixtureswhichareintendedforuseascalibrationga
39、smixtures).Suchapplications,however,needappropriatecareandconsiderationofadditionaluncertaintycomponents,forexample,concerningtheeffectofmatrixdifferencesbetweenthereferencegasesusedforcalibrationandtheanalysedsample.NOTE2Comparisonmethodsbasedonone-andtwo-pointcalibrationaredescribedinISO12963.2 No
40、rmativereferencesTherearenonormativereferencesinthisdocument.3 TermsanddefinitionsForthepurposesofthisdocument,thefollowingtermsanddefinitionsapply.ISOandIECmaintainterminologydatabasesforuseinstandardizationatthefollowingaddresses:一ISOOnlinebrowsingplatform:availableathttps:WWW.iso.orgobp一IECElectr
41、opedia:availableathttps:/www.electropedia.org/3.1compositioncharacteristicofagasmixturegivenbythekindandcontentofeachspecifiedmixturecomponent(analyte)andaspecificationofthecomplementarygas(matrix)Note1toentry:Inthisdocument,theanalytecontentisspecifiedasanamount-of-substancefraction,exclusively.Amo
42、untfractionshavetheadvantageofbeingperfectlyindependentofthepressureandthetemperatureofthegasmixture.Therefore,theiruseisrecommended.However,forspecificmeasuringsystems,othercompositionmeasures(e.g.massconcentrations)canbemoreappropriate.Theirusethenrequiresduecareconcerningthedependenceonpressurean
43、dtemperature.MethodsforconversionbetweendifferentquantitiesofcompositionarespecifiedinISO14912.3.2comparisonmethodmethodfordeterminingthecontentofaspecifiedgasmixturecomponent(analyte)bymeasuringaninstrumentresponseNote1toentry:Comparisonmeasuringsystemsrequirecalibration,inwhichtherelationshipbetwe
44、enresponseandanalytecontentisestablished.Thisisachievedbymeasuringtheresponsetoknownvaluesofanalytecontentprovidedbyreferencegasmixtures.3.3calibrationoperationthat,underspecifiedconditions,inafirststep,establishesarelationbetweenthequantityvalueswithmeasurementuncertaintiesprovidedbymeasurementstan
45、dardsandcorrespondingindicationswithassociatedmeasurementuncertaintiesand,inasecondstep,usesthisinformationtoestablisharelationforobtainingameasurementresultfromanindicationSOURCE:ISO/IECGuide99:2007,2.393.4responsefunctionfunctionalrelationshipbetweeninstrumentresponseandanalytecontentNote1toentry:
46、Theresponsefunctioncanbeexpressedintwodifferentwaysasacalibrationfunction(3.4.1)orananalysisfunction(3.4.2),dependingonthechoiceofthedependentandtheindependentvariable.3.4.1calibrationfunctioninstrumentresponseexpressedasafunctionofanalytecontent3.4.2analysisfunctionanalytecontentexpressedasafunctio
47、nofinstrumentresponse3.5measurementuncertaintyuncertaintyofmeasurementuncertaintynon-negativeparametercharacterizingthedispersionofthequantityvaluesbeingattributedtoameasurand,basedontheinformationusedSOURCE:ISO/IECGuide99:2007,2.263.6measurementstandardrealizationofthedefinitionofagivenquantity,wit
48、hstatedquantityvalueandassociatedmeasurementuncertainty,usedasareferenceSOURCE:ISO/IECGuide99:2007,5,13.7referencestandardreferencemeasurementstandardmeasurementstandard(3.6)designatedforthecalibrationofothermeasurementstandardsforquantitiesofagivenkindinagivenorganizationoratagivenlocationSOURCE:ISO/IECGuide99:2007,5.63.8 calibrationgasmixturegasmixtureofknownstabilityandhomogeneitywhosecompositioniswellestablishedforuseinthecalibrationorverificationofameasuri
